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Help develop novel treatments for rare disease patients

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Bioinformatician

Bioinformatician

About Healx

Healx is an AI-powered tech bio company that is redesigning drug discovery. With 10,000 rare diseases affecting 400 million people globally, 90% of which have no approved treatment, Healx is on a mission to pioneer the next generation of drug discovery to help rare disease patients in need. We combine data, artificial intelligence and deep pharmacology expertise to develop treatments more quickly and cheaply than traditional drug discovery.

Diversity and inclusion sits at the heart of our mission to help people with rare diseases, and we believe that attracting and empowering a diverse team is critical to achieving this goal. We welcome applications from people from all backgrounds and walks of life.

Below we have included the qualities that we feel are required for you to excel in this role; however we appreciate that people can apply transferable skills from all walks of life and experience. If you think you have what it takes, love our mission and resonate with our values but are worried you don't tick every box – we still want to hear from you and encourage you to apply!

Our values

• Care for Rare – Rare disease patients are at the heart of what we do

• Grow as individuals – We are learners always seeking to enhance our expertise

• Win as a team – We strive to remain inclusive and diverse and we celebrate successes and lessons together

• Innovate and deliver – Our mission requires rapid innovation and calculated risks that won’t compromise our high standards

The role

Healx is looking for an enthusiastic Bioinformatician to join the Digital Sciences team to play a key role in Bioinformatic activities that improve outcomes for rare disease patients by discovering drug combination therapies with improved efficacy and safety over standard of care. This role will enhance the capabilities of our AI Drug Discovery Platform. You will support development of novel algorithms for the prediction of drug synergy and polypharmacology required by our growing portfolio of Rare Neurology and Oncology Programmes. You will partner closely with and report to the Senior Director of Digital Science to plan, develop and deliver algorithms and bioinformatic workflows that generate therapeutic hypotheses. You’ll be closely collaborating with Pharmacologists, Biocurators, Data Engineers, Bioinformaticians, Cheminformaticians and Machine Learning Engineers & Scientists to deliver in silico predictions that will be experimentally tested. Owing to the unique cross functional and highly collaborative Healx Team, the research you perform will be rapidly translated to meaningful outcomes, with the potential to improve patient quality of life.

Key responsibilities

Application of drug combination prediction algorithms to generate and rationalise novel therapeutic hypotheses for Healx portfolio of rare diseases

Innovation and improvement of Healx drug combination technologies

Supporting the Healx Preclinical Team to deliver the best outcomes for rare disease patients by ensuring our AI Discovery Platform is maintained

You will know you are successful when

Digital Science delivers the best treatment predictions with highest chance of clinical and commercial success to our Pharmacologists

Algorithm and workflow improvements you’ve contributed are applied in active Preclinical Discovery Programmes

You are actively developing high quality code in collaboration with colleagues, and receiving great feedback on your commits

What we're looking for

You have experience in Biotech or Pharma Bioinformatics, a background in human disease biology, and you’re now looking for your next challenge. You are excited about taking on new projects and responsibilities in a mission-driven startup. We'd love to hear from you if your experience and interest overlaps with this profile:

Bioinformatics, especially processing multiomics, compound bioactivities or other life sciences data for the discovery of drug combinations

Reduction of algorithms to code, especially in Python, R, and Nextflow Pipelines

Hands-on and collaborative approach to Bioinformatic algorithm and workflow development

Interest in biotech/ techbio and its impact of improving patient outcomes

It’s a bonus if you have:

Experience estimating synergy, polypharmacology or adverse events

Familiarity with network biology methods, elucidation of signalling pathways and gene set enrichment

A keen interest in Bioinformatic Engineering standards

A background in health-tech or life sciences

Working at Healx

Healx works from a modern accessible office in the centre of Cambridge within easy reach of the train station. We offer a flexible, diverse and inclusive working environment that considers your individual needs and believes in maintaining a sustainable work-life balance and we are open to discussing flexible working arrangements. You will be welcomed by a team of colleagues with decades of accumulated experience in their areas of expertise, happy to help you develop your own skills in a highly collaborative environment and who are keen to provide guidance and support in your personal and career development plans. Healx is a distributed team, and operates a hybrid working model. Healx will provide you with support and guidance to help you do your best work and make an impact. We offer flexible working and believe in maintaining a sustainable work-life balance. If you require any reasonable adjustments during the recruitment process, please let us know — we’re happy to accommodate

What’s on offer

• Financial - Competitive salary, share options, 7% employer pension contributions, life insurance of 4x base salary

• Health and Wellbeing - Private medical insurance, 25 days annual leave (plus bank holidays) with the option to purchase additional days to support a healthy work-life balance, wellbeing support via Spill and our Employee Assistance Programme

• Hybrid Working - Flexible and remote working options, home office set-up allowance, periodic in-person team days for company-wide collaboration and celebration

• Family Friendly - Enhanced family leave policies and flexible working practices

• Personal Development and Growth - Personal learning and development budgets, regular personal development conversations and career support

• Community Engagement and Support - One paid day off per year to volunteer for a cause aligned with our mission of supporting patients living with rare diseases; the opportunity to hear from and engage with patient groups and communities who offer us valuable insights into the experiences of those affected by rare diseases

Platform Engineer

About Healx

Our values

• Care for Rare – Rare disease patients are at the heart of what we do

• Grow as individuals – We are learners always seeking to enhance our expertise

• Win as a team – We strive to remain inclusive and diverse and we celebrate successes and lessons together

• Innovate and deliver – Our mission requires rapid innovation and calculated risks that won’t compromise our high standards

The role

Healx is hiring a motivated Platform Engineer to build cloud infrastructure and develop production pipelines that enable our AI drug discovery process. You will bridge the gap between infrastructure and scientific software, both designing, building and supporting cloud infrastructure and collaborating with bioinformaticians, machine learning engineers and data scientists to implement data pipelines.

You will join a small, agile engineering team where individuals take ownership of tasks, innovate quickly and collaborate extensively through pair programming. Working closely with technical members of data and digital science teams you will clearly see the impact your work has on pioneering the next generation of AI drug discovery and finding treatments for rare disease patients in need.

How we work with AI coding tools

Our engineers understand and use AI development tools to solve problems and implement systems efficiently while retaining responsibility for system design, implementation and testing of code. We aim to move quickly while building systems we understand deeply and can maintain.

Key Responsibilities

Design, build, maintain and improve cloud infrastructure in AWS (and some GCP) to enable AI drug discovery workflows

Follow infrastructure as code (IaC) and CI/CD principles to build maintainable infrastructure using Terraform and CircleCI

Take advantage of latest AWS tools and apply best practices across our cloud estate to ensure security, availability and observability

Work closely with technical users across the company to understand and support their computational needs

In collaboration with data scientists write code to build, test and automate production pipelines in tools such as Nextflow, Airflow, MLflow and KNIME

Embrace the use of AI coding tools and agents to accelerate delivery while retaining responsibility for system design, implementation and testing of code

You will know you are successful when

You have strong ownership of parts of our cloud infrastructure, familiarity with our Terraform codebase and are shipping regular improvements

Infrastructure you've designed and deployed is supporting drug discovery pipelines

You have taken ownership of security, cost management and observability in our cloud estate

Computational workflows are in production that you've built in Nextflow, Airflow, MLflow or similar in collaboration with digital scientists

You have shipped maintainable code to enable lambda functions, automation scripts and internal tools in several of our Python repositories

What we're looking for

We're looking for a mid level engineer with solid hands on experience building cloud infrastructure in a commercial environment who is keen to apply what they already know and learn new skills.

You are highly collaborative and driven to solve problems that help others and drive the Healx mission

You have hands-on experience (typically around 2+ years) working with a cloud platform, ideally AWS, and are excited about building cloud infrastructure following best practices

You are a proponent and practitioner of infrastructure as code principles, ideally with experience in Terraform, and have experience building, maintaining and scaling CI/CD pipelines

Solid experience writing maintainable and well tested code following best practices in at least one language (we use mainly Python and some Go)

An automation mindset, ideally with experience building production workflows in tools like Airflow

Working at Healx

We are a hybrid team operating on a highly collaborative model that values synchronization and pair programming. If you are excited about the role but are unsure whether your location aligns perfectly, we encourage you to apply and start a conversation. If you are remote, you are expected to attend workshops in Cambridge every couple of months.

You will be welcomed by a team of colleagues with decades of accumulated experience in their areas of expertise, happy to help you develop your own skills in a highly collaborative environment and who are keen to provide guidance and support in your personal and career development plans.

Healx will provide you with support and guidance to help you do your best work and make an impact. We offer flexible working and believe in maintaining a sustainable work-life balance. If you require any reasonable adjustments during the recruitment process, please let us know — we’re happy to accommodate

What’s on offer

• Financial - Competitive salary, share options, 7% employer pension contributions, life insurance of 4x base salary

• Hybrid Working - Flexible and remote working options, home office set-up allowance, periodic in-person team days for company-wide collaboration and celebration

• Family Friendly - Enhanced family leave policies and flexible working practices

• Personal Development and Growth - Personal learning and development budgets, regular personal development conversations and career support

Start making a difference

Our mission is to achieve unprecedented rare disease impact by pioneering the next generation of drug discovery.

There are over 7,000 known rare diseases that affect 400 million people across the globe, but only 5% of those conditions have an approved treatment. By joining us you are helping build new treatments to tackle this huge unmet need.

Our people and culture

Our team is a diverse mix of expertise, experience and perspectives, but what unites us is our drive to make a positive difference to rare disease patients and their families.

We’re proud of our inclusive culture where individuals are encouraged to collaborate, lead and grow.

Diversity, Equity and Inclusion Learn about us